LymphedemaV1, Main, Exploration, bibRecord, 005E99

A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients

Identifieur interne : 005E99 ( Main/Exploration ); précédent : 005E98; suivant : 005F00

A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients

Auteurs : Isabelle Bedrosian [États-Unis] ; Gildy V. Babiera [États-Unis] ; Elizabeth A. Mittendorf [États-Unis] ; Henry M. Kuerer [États-Unis] ; Laura Pantoja [États-Unis] ; Kelly K. Hunt [États-Unis] ; Savitri Krishnamurthy [États-Unis] ; Funda Meric-Bernstam [États-Unis]

Source :

Cancer [ 0008-543X ] ; 2010.

RBID : Pascal:10-0275226

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle (anatomopathologie), Femelle, Humains, Lymphadénectomie (), Lymphoedème (), Métastase lymphatique, Sujet âgé, Tumeurs du sein (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie), Études de faisabilité.
MESH :
- anatomopathologie : Aisselle, Tumeurs du sein, Vaisseaux lymphatiques.
Pascal (Inist)
- Adulte, Adulte d'âge moyen, Essai clinique phase I, Femelle, Humains, Lymphadénectomie, Lymphoedème, Métastase lymphatique, Sujet âgé, Traitement, Faisabilité, Cartographie, Axillaire, Réversibilité, Cancer du sein, Homme, Creux axillaire, Lymphoedème, Lymphadénectomie, Essai clinique, Cancérologie, Études de faisabilité.
Wicri :
- topic : Cartographie, Homme.

English descriptors

KwdEn :
- Adult, Aged, Axilla, Axilla (pathology), Axillary, Breast Neoplasms (pathology), Breast cancer, Cancerology, Cartography, Clinical trial, Feasibility, Feasibility Studies, Female, Human, Humans, Lymph Node Excision (methods), Lymphadenectomy, Lymphatic Metastasis, Lymphatic Vessels (pathology), Lymphedema, Lymphedema (prevention & control), Middle Aged, Phase I trial, Reversibility, Treatment.
MESH :
- methods : Lymph Node Excision.
- pathology : Axilla, Breast Neoplasms, Lymphatic Vessels.
- prevention & control : Lymphedema.
- Adult, Aged, Feasibility Studies, Female, Humans, Lymphatic Metastasis, Middle Aged.

Abstract

BACKGROUND: Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were conducted in early stage patients with low likelihood of lymph node metastasis. This study reported a phase 1 trial conducted in patients with cytologically documented axillary metastasis undergoing axillary lymph node dissection to determine the feasibility and oncologic safety of ARM. METHODS: Thirty patients, 23 (77%) of whom received preoperative therapy (chemotherapy in 22 patients and hormonal therapy in 1 patient), were enrolled. Blue dye was injected in the upper inner ipsilateral arm. The presence of blue lymphatics was noted, and blue lymph nodes were sent separately for pathologic evaluation. RESULTS: The average time between blue dye injection and axillary exposure was 35 minutes (range, 15-60 minutes). Blue lymphatics were identified in 21 patients (70%) and blue lymph nodes in 15 patients (50%). The median number of ARM lymph nodes was 1 (range, 0-3 lymph nodes) and the median number of axillary lymph nodes was 26 (range, 6-47 lymph nodes). Axillary metastases were noted in 60% (18 of 30) of patients. Of 11 patients who had axillary metastasis and at least 1 ARM lymph node identified, 2 (18%) had metastasis to the ARM lymph node. CONCLUSIONS: ARM appears to be a feasible technique with which to identify upper arm lymphatics during axillary surgery. However, the high prevalence of disease involving ARM lymph nodes in this small cohort suggested that preservation of these lymphatics is not oncologically safe in women with documented axillary lymph node metastasis from breast cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406355

Affiliations:

États-Unis

Le document en format XML

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<series><title level="j" type="main">Cancer</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Axilla</term>
<term>Axilla (pathology)</term>
<term>Axillary</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast cancer</term>
<term>Cancerology</term>
<term>Cartography</term>
<term>Clinical trial</term>
<term>Feasibility</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Lymph Node Excision (methods)</term>
<term>Lymphadenectomy</term>
<term>Lymphatic Metastasis</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema</term>
<term>Lymphedema (prevention & control)</term>
<term>Middle Aged</term>
<term>Phase I trial</term>
<term>Reversibility</term>
<term>Treatment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aisselle (anatomopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphadénectomie ()</term>
<term>Lymphoedème ()</term>
<term>Métastase lymphatique</term>
<term>Sujet âgé</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
<term>Études de faisabilité</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aisselle</term>
<term>Tumeurs du sein</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymph Node Excision</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Axilla</term>
<term>Breast Neoplasms</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphatic Metastasis</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Essai clinique phase I</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphadénectomie</term>
<term>Lymphoedème</term>
<term>Métastase lymphatique</term>
<term>Sujet âgé</term>
<term>Traitement</term>
<term>Faisabilité</term>
<term>Cartographie</term>
<term>Axillaire</term>
<term>Réversibilité</term>
<term>Cancer du sein</term>
<term>Homme</term>
<term>Creux axillaire</term>
<term>Lymphoedème</term>
<term>Lymphadénectomie</term>
<term>Essai clinique</term>
<term>Cancérologie</term>
<term>Études de faisabilité</term>
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<term>Homme</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND: Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were conducted in early stage patients with low likelihood of lymph node metastasis. This study reported a phase 1 trial conducted in patients with cytologically documented axillary metastasis undergoing axillary lymph node dissection to determine the feasibility and oncologic safety of ARM. METHODS: Thirty patients, 23 (77%) of whom received preoperative therapy (chemotherapy in 22 patients and hormonal therapy in 1 patient), were enrolled. Blue dye was injected in the upper inner ipsilateral arm. The presence of blue lymphatics was noted, and blue lymph nodes were sent separately for pathologic evaluation. RESULTS: The average time between blue dye injection and axillary exposure was 35 minutes (range, 15-60 minutes). Blue lymphatics were identified in 21 patients (70%) and blue lymph nodes in 15 patients (50%). The median number of ARM lymph nodes was 1 (range, 0-3 lymph nodes) and the median number of axillary lymph nodes was 26 (range, 6-47 lymph nodes). Axillary metastases were noted in 60% (18 of 30) of patients. Of 11 patients who had axillary metastasis and at least 1 ARM lymph node identified, 2 (18%) had metastasis to the ARM lymph node. CONCLUSIONS: ARM appears to be a feasible technique with which to identify upper arm lymphatics during axillary surgery. However, the high prevalence of disease involving ARM lymph nodes in this small cohort suggested that preservation of these lymphatics is not oncologically safe in women with documented axillary lymph node metastasis from breast cancer.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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   |texte=   A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients
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Serveur d'exploration sur le lymphœdème

A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients

A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients

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	Serveur d'exploration sur le lymphœdème
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